Experimental design This study aimed to develop an ex vivo 3D organotypic model of the epicardial/myocardial interface, which would enable studies directed at identifying mechanisms of adult epicardium reactivation. Our experiments verified the maintenance of the tissue architecture in the slices and the preservation of a living and healthy epicardial cells monolayer and myocardial tissue.
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The Swiss startup EraCal Therapeutics has signed a research partnership with the Danish pharmaceutical giant Novo Nordisk to search for treatments controlling food intake and other factors contributing to obesity.  Under the joint project, EraCal and Novo Nordisk will research targets for obesity treatments by identifying molecules that can control appetite and improve metabolic health.
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Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health report successfully removing the nucleus out of a type of ubiquitous cell, known as enucleation, then using the genetically engineered cell as a unique cargo-carrier to deliver therapeutics precisely to diseased tissues. The findings published in
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Clinical stage outfit, Destiny Pharma, provides a positive summary of the year ahead Clinical stage outfit, Destiny Pharma, has announced an update of its late-stage clinical assets, providing a positive summary of prospects for the year ahead. Indeed, it is safe to say that the innovative biotechnology company has much to be optimistic about, with
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A recent study published in the journal The Lancet Regional Health (Europe) shows how smoking can be linked with increased social isolation and loneliness in older individuals, implying it can have detrimental effects on several different aspects of their psychosocial health. Study: Relationship of smoking with current and future social isolation and loneliness: 12-year follow-up
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A World Health Organization (WHO) panel has given the green light to two new drugs to treat COVID-19. US-based Eli Lilly’s baricitinib (Olumiant), a Janus kinase inhibitor, and GlaxoSmithKline and Vir Biotechnology’s sotrovimab, a monoclonal antibody, were recommended in new WHO guidelines, published in the British Medical Journal.  Baricitinib, administered with corticosteroids, was strongly recommended as
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Ecologists need to understand wild animal behaviours in order to conserve species, but following animals around can be expensive, dangerous, or sometimes impossible in the case of animals that move underwater or into areas we can’t reach easily. Ecologists need to understand wild animal behaviours in order to conserve species, but following animals around can
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We have here conducted a comparative analysis using two NGS platforms to clarify the structure of the sSMC in two different patients. We first performed WGS using an Illumina short-read sequencer. Without enrichment, 99% of all the sequence reads were mapped to an off-target region and thus wasted. To avoid this, we applied adaptive sampling,
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Natural selection causes a virus to enhance its evolutionary advantages either by mutations that strengthen its binding with the host cell or by mutations to escape antibody protection. A recent study, published in the Journal of Chemical Information and Modeling, uses an artificial intelligence model to investigate Omicron’s mutations and its infectivity, vaccine escape capability,
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The details are slim, but Novo Nordisk seems to be in the clear after shareholders took the diabetes juggernaut to court nearly three years ago over the company’s public communications about its struggling insulin business. Novo Nordisk said Friday that it’s settled a Danish securities lawsuit from the summer of 2019. The agreement “contains no
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Despite diagnosis and treatment options improving for the rare kidney condition, further action is urgently required. Kidney Research UK and the Stoneygate Trust have announced new Manchester-based research programme dedicated to the study and treatment of the rare kidney condition, Alport syndrome, which is to begin work in early 2022. The Manchester-based research hub aims
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Ever since the emergence and rapid spread of severe acute respiratory syndrome coronavirus (SARS-CoV) in southern China in 2002, scientists have considered coronaviruses to be a potential threat to humans. Another member of the coronavirus family, namely, Middle East respiratory syndrome coronavirus (MERS-CoV), showed high transmission and mortality rate; however, it did not spread across
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A University of Texas at Arlington aerospace engineer is teaming with industry partners to develop control systems for autonomous aerial vehicles that will increase their safety and detect structural issues. A University of Texas at Arlington aerospace engineer is teaming with industry partners to develop control systems for autonomous aerial vehicles that will increase their
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Materials Recombinant human Met ectodomain-Fc, rhEPOR ectodomain-Fc, and rhHGF were purchased from R&D Systems (Minneapolis, MN, USA). rhEPO and rhTPO were purchased from Peprotech, Inc. (Rocky Hill, NJ, USA). Monomeric macrocyclic peptides (aMD4dY and EMP35) were synthesized by GenScript Japan (Tokyo, Japan). Ammonium acetate was purchased from Nacalai Tesque (Kyoto, Japan). Thermolysin and ProAlanase were
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