Rare diseases affect a fraction of the population – 450 million+ people globally. However, its effects can be equally severe and life-threatening as other prevalent diseases. For Rare Disease Day, Tarun Kumar Bansal discusses why we need to expedite innovation in the rare disease domain. Every time a patient with a rare condition walks into
Month: February 2021
Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI. This research outcome was published in PNAS, a world-renowned academic journal. * (Title) Prediction of Alzheimer’s Disease-Specific phospholipase
Genentech has partnered with the University of California (UC), San Francisco and UC Berkeley to work on neuroscience drugs. The Roche subsidiary has committed up to $53 million to collaborate with the academics on areas such as neurodegeneration over the next 10 years. The genesis of the collaboration dates back to 2019, when UCSF, UC
Natural killer cells are becoming a hot topic in the booming cancer cell therapy scene, with the field’s latest big deal being a €640M licensing agreement between the French biotech Cellectis and US company Cytovia. T-cell immunotherapies like CAR T-cell therapy have revolutionized cancer treatment in recent times. However, they have a significant disadvantage. The
Abundant expression of Postn in neonatal tendons The basic building blocks of tendons are type-I ECM collagen fibers, which are composed of highly parallel-aligned fibrils deposited by tendon cells. The number of proliferating cells was reported to be greater in the tendon ECM niche from 3-day-old mice than from 6-week-old mice2. Compared to the 6–8-week-old
Insilico Medicine has demonstrated a breakthrough in Artificial Intelligence (“AI”) and drug discovery — linking together generative chemistry and biology for the first time — to discover a novel preclinical candidate addressing idiopathic pulmonary fibrosis (“IPF”) and be validated with multiple human cell and animal model experiments. Often found implicated in a wide range of
The global pandemic promised a windfall for forward-thinking companies making products to help combat the spread of the coronavirus. Count the Stevanto Group, one of the world’s foremost makers of glass vials, among them. Since the onset of the pandemic, business has been booming at the 72-year-old Italian company, so much so that Stevanto is
Dublin-based clinical trials group ICON is set to acquire rival contract research organisation (CRO) PRA Health Sciences in a deal worth approximately $12bn. The deal will see the two global organisations join together to create a major clinical trial provider to pharma companies. In a statement, ICON said that the merger will see biopharma and
A University of Texas at Arlington researcher has received an Office of Naval Research (ONR) grant to examine the mechanics of how blast-like events cause damage to the brain. Ashfaq Adnan, professor of mechanical and aerospace engineering, has received a three-year, $944,845 grant to study the potential link between blast-like trauma and cellular and tissue
A University of Texas at Arlington researcher has received an Office of Naval Research (ONR) grant to examine the mechanics of how blast-like events cause damage to the brain. Ashfaq Adnan, professor of mechanical and aerospace engineering, has received a three-year, $944,845 grant to study the potential link between blast-like trauma and cellular and tissue
Artiva Biotherapeutics has raised $120 million to advance a pipeline of allogeneic natural killer (NK) cell therapies. The Merck-partnered biotech has an unmodified NK cell therapy in the clinic and a clutch of CAR-engineered candidates following close behind. San Diego-based Artiva is one of a number of biotechs built on the idea that NK cells
A recent patent fight between the liquid biopsy companies Natera and Inivata is only the latest of many spats over DNA sequencing technology that could potentially revolutionize the detection and treatment of cancer. Earlier this month, the UK-US biotech Inivata raised €29M in the second closing of a Series C round. The company will use
Field attributes of indigenous farmer’s varieties collected from sub-Himalayan Terai region A total of ninety-nine genotypes collected from different region of sub-Himalayan Terai region were subjected to purity breeding for at least five years and the pure lines were deposited to the Uttar Banga Krishi Viswavidyalaya (UBKV) rice repository. The performance of the genotypes for morphological and
The World Health Organization greenlighted emergency use of AstraZeneca and Oxford’s covid-19 vaccine this month, following in the steps of the United Kingdom, the European Union and others, who are already injecting it as quickly as possible into the masses. But the United States is still waiting. As covid deaths mount daily, critics say the
A month after Johnson & Johnson’s COVID-19 vaccine posted positive data in a phase 3 study, the shot is almost ready for prime time. Late Friday, a key panel unanimously endorsed the vaccine for emergency use and sent it to the agency for an official decision. An FDA authorization for the one-dose vaccine would provide a quick lift
Wayra and GE Healthcare have launched an accelerator programme across the Europe, the Middle East and Africa (EMEA) region to support digital health start-ups to develop AI applications for healthcare. The Edison Accelerator will initially support six start-ups in its first cohort, which will focus on applying AI to medical imaging, operational AI in oncology
UK-based doctor, Dr Natasha Larmie is on a mission to make medicine weight inclusive. Inspired by the Health at Every Size movement, Natasha is campaigning to take the weighing scales out of general practice and focus instead on health promoting behaviours. Last year, as the pandemic escalated worldwide, UK GP Dr Natasha Larmie embarked on
Researchers at the Lady Davis Institute (LDI) at the Jewish General Hospital have discovered that increased levels of the protein OAS1 are associated with reduced mortality and less severe disease requiring ventilation among patients with COVID-19. Using drugs that boost OAS1 levels could be explored to try to improve these outcomes. The findings are published
UNIVERSITY PARK, Pa. — A new type of housing modification can reduce malaria incidence among children by around 40-50%, according to an international team of researchers. The intervention uses window screening, together with PVC tubes fitted with insecticide-laced screens and installed under the eaves of homes, as a novel method of killing malaria mosquitoes as
Merck has struck a $1.9 billion deal to buy Pandion. The takeover will give Merck control of a pipeline of immune modulators led by a rival to IL-2 drugs in development at Amgen, Eli Lilly and Roche. Pandion went public last year, pulling in $135 million to fund the development of a pipeline led by
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