Month: March 2021

University of Missouri scientists receive $4 million grant from the National Institutes of Health to examine clues about the rate of infection in communities and virus variants Everyone poops, and now scientists are using this bodily function to develop a detailed analysis of the virus that causes COVID-19, known as SARS-CoV-2. After cases of COVID-19
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Shortly after unveiling plans to spin its multibillion-dollar women’s health portfolio into the new company Organon, Merck & Co. has already lined up what will be its first acquisition: Alydia Health, which makes a device designed to prevent a mother’s death during childbirth. One of this year’s Fierce Medtech Fierce 15, Alydia is slated to receive a
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An emerging new electrophysiology technology, known as high-density microelectrode arrays, enables researchers to study in vitro models of human brain disease in detail. This creates new possibilities to understand the underlying mechanisms of neurological disorders, like Parkinson’s disease and amyotrophic lateral sclerosis, and advance therapy development. Michele Fiscella, Vice President Scientific Affairs, MaxWell Biosystems The
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Structural analyses of Ffase with polyols as fructosyl-acceptors As explained before, the crystallographic study of the Ffase homodimer and its subsequent evaluation by site-directed mutagenesis disclosed the key determinants for its transfructosylating activity with sucrose. The pair Gln-228/Asn-254, and to a lesser extent Gln-176/Arg-178, was found to have an important role for regulating the biocatalytic
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RedHill Biopharma Ltd. (“RedHill” or the “Company”), a specialty biopharmaceutical company, today announced that it has acted on a request to provide opaganib treatment on an outpatient basis under compassionate use exemption for several Swiss patients suffering from COVID-19 pneumonia. Acting rapidly to ensure emergency transport and supply of drug, treatment was initiated with orally-administered
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Eli Lilly faced a high-level personnel scandal last month when CFO Josh Smiley left under a cloud of “inappropriate” communications with employees. But a sex discrimination lawsuit from a former internal lobbyist uncovers an entirely new controversy—and offers an alleged look inside the culture of a key team. Sonya Elling, a longtime biopharma lobbyist who
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Following the success of J+D’s face to face training, the content has been redesigned to make it suitable for an online audience. The training can be tailored to individual teams/departments within specific organisations or completed independently. There is a significant need for an improved approach to pharmaceutical forecasting. Improved model design, enhanced usability, efficient processes
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Today, the U.S. Food and Drug Administration announced it is allowing the use of the Binx Health IO CT/NG Assay at point-of-care settings, such as in physician offices, community-based clinics, urgent care settings, outpatient health care facilities and other patient care settings, operating under a CLIA Certificate of Waiver, Certificate of Compliance or Certificate of
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Bioengineering researchers at Lehigh University have identified a previously unknown interaction between receptors in human cells and the spike, or “S,” protein of SARS-CoV-2, the virus that causes COVID-19. This new information could aid in the development of new strategies to block SARS-CoV-2 entry into human cells. X. Frank Zhang and Wonpil Im knew from
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Alkermes’ virtual R&D day went down well with analysts, as it showed off a few early-stage incremental updates and reiterated its attempts for seeking out some new ops and collabs. On the R&D side, there were several small updates, including for its closely watched engineered IL-2 variant immunotherapy nemvaleukin alfa (ALKS-4230), which reported new single
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Mice Wild-type C57BL/6 mice were obtained from the Monash Animal Research Platform. BKS.Cg-Dock7m +/+ Leprdb/J (Leprdb/db) mice were obtained from the Jackson Laboratory. Because Leprdb/db mice are sterile, Leprdb/+ mice were crossed to Il1r1−/− mice21 to obtain fertile Leprdb/+–Il1r1−/+ mice. Then, Leprdb/+–Il1r1−/+ were crossed together to obtain Leprdb/db–Il1r1−/− mice. Animals were kept under specific pathogen-free conditions.
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Antibody injections are a highly desirable treatment for people with chronic diseases such as cancer, psoriasis, Crohn’s disease and arthritis. And recently, antibodies have been in the news as a promising treatment for severe cases of COVID-19. But the costly, time-consuming manufacturing process to produce antibodies prevents these treatments from being accessible to most patients.
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After multiple regulatory setbacks on Bristol Myers Squibb’s lymphoma CAR-T drug Breyanzi caused investors headaches, the company on Friday scored its second cell therapy approval. The FDA endorsed Abecma—formerly known as idecabtagene vicleucel, or ide-cel—to treat adults  whose multiple myeloma has progressed after at least four previous rounds of treatment. It’s the first CAR-T med approved in multiple myeloma and the first CAR-T in
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A new research project, announced by the UK’s Drug Safety Research Unit (DSRU), will aim to improve understanding of differing decisions on medicine use between different countries and regions. The Global Pharmacovigilance Observatory will review pharmacovigilance and drug safety data, as well as analyses, evaluations and decisions made in different countries. The resulting information will
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Odontoblasts, the cells that form a tooth’s dentin, have a newly discovered function: Sensing cold, which can trigger pain in teeth; but scientists have also found a way to block the pathway to cold-sensitive teeth BOSTON — Researchers report in Science Advances that they have uncovered a new function for odontoblasts, the cells that form
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A new study suggests that clearing the invasive woody weed Prosopis julifora and grassland restoration in Baringo County, Kenya, may have significant financial benefits for local stakeholders and contribute to climate change mitigation. A new study suggests that clearing the invasive woody weed Prosopis julifora and grassland restoration in Baringo County, Kenya, may have significant
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