Month: April 2021

CAR-T therapies that use engineered versions of patients’ own immune cells to recognize cancer antigens have shown great efficacy in certain blood cancers. But they’ve been largely ineffective against solid tumors because of a lack of tumor-specific antigens and the tendency of CAR-Ts to wither in an immunosuppressive tumor microenvironment. Now two teams of scientists at the
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Bristol Myers Squibb’s recent phase III success provided the first late-stage confirmation for a novel immune checkpoint target in nearly a decade. This could herald the next generation of checkpoint inhibitors against cancer. Last month, the antibody drug relatlimab, developed by Bristol Myers Squibb, increased the progression-free survival of melanoma patients in phase III. These
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In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. With this technology,
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With Merck’s sales dragging from the pandemic and the company becoming increasingly reliant on immuno-oncology superstar Keytruda, the pharma giant’s executive team unveiled a willingness to flex its M&A muscle. “We are open to any opportunity to add a meaningful asset,” president and soon-to-be CEO Rob Davis said on a Thursday call with investors. “We
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The 2021 Marketer of the Year competition is well underway for entries and is looking for the best and brightest to join the ranks. This industry-renowned competition is seeking out the brightest sparks in the pharma marketing sector to enter the competition and show off their skills. It’s the perfect opportunity to take the learnings
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The ability to turn on and off a physical process with just one photon is a fundamental building block for quantum photonic technologies. Realizing this in a chip-scale architecture is important for scalability, which amplifies a breakthrough by City College of New York researchers led by physicist Vinod Menon. They’ve demonstrated for the first time
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One popular theory in the quest to develop cures for Alzheimer’s disease is that targeting the toxic clumps of the protein beta-amyloid in the brain that are a hallmark of the disease could ameliorate symptoms. One such anti-amyloid drug, Biogen and Eisai’s aducanumab, has shown mixed efficacy in slowing cognitive decline in two clinical trials, while
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With two partnered drugs in the clinic, Exscientia is reeling in up to $525 million to push its own pipeline into clinical testing and continue developing an artificial intelligence-based technology toward autonomous drug design. SoftBank Vision Fund 2 led the $225 million series D financing, in which a dozen other investors participated, including BlackRock, Novo
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Company culture can be essential to the success of a biotech company. Sabine Dandiguian, Managing Partner at the life sciences VC firm Jeito Capital, shares her experience building a thriving company culture in the life sciences. Company culture is “something very special” that borders on collective intelligence, says Sabine Dandiguian. There are some basics to
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Agriculture sector in Iran has been one of important and relatively stable economic sectors of the country with about 14–15% share of gross domestic product (GDP) despite the unprecedented sanctions over the recent years. Moreover, this sector accounts for about 20% of employment rate in Iran while only 5% of direct employment of individuals in
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Experimental animals and animal care The care and experimental use of chickens was approved by the Institute of Laboratory Animal Resources, Seoul National University. Chickens were maintained according to a standard management program at the University Animal Farm, Seoul National University, Korea. All procedures, including chicken maintenance, reproduction, and sample collection, were governed by standard
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A promising new concept published by an interdisciplinary research team in “Proceedings of the National Academy of Sciences” (PNAS) paves the way for major advances in the field of magnetic resonance imaging (MRI). Their new technique could significantly simplify hyperpolarized MRI, which developed around 20 years ago for observing metabolic processes in the body. The
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Johnson & Johnson has been hit with billions in talc verdicts, but it’s had mixed success in appeals. With a new decision Wednesday, the company chalked up its latest appeals win.  A court in J&J’s home state of New Jersey struck down a $117 million verdict against the drugmaker originally handed down there in 2018, Bloomberg reports. The court ruled that the
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