Month: May 2021

These Oncotarget findings suggest that PL reduces tumor growth and induces cell death by regulating the cell cycle Oncotarget published “Piperlongumine promotes death of retinoblastoma cancer cells” which reported that while retinoblastoma initiation is triggered by the inactivation of both alleles of the retinoblastoma tumor suppressor gene in the developing retina, tumor progression requires additional
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                Welcome to this week’s Chutes & Ladders, our roundup of hirings, firings and retirings throughout the industry. Please send the good word—or the bad—from your shop to Fraiser Kansteiner, and we will feature it here at the end of each week. Next-gen T-cell player Neogene bolsters U.S. team, adding Bristol Myers vet as COO Neogene
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Development of the mapping population The cross between TMS98/0505 and TMS98/0581 (Population B parental lines) gave good flowering to generate seeds. There was good genetic variation in plant formation at the nursery. While a high number of the seedlings showed good development, many of the genotypes had extremely stunted growth. Once a genotype could support
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Malignant tumor cells undergo mechanical deformation more easily than normal cells, allowing them to migrate throughout the body. The mechanical properties of prostate cancer cells treated with the most commonly used anti-cancer drugs have been investigated at the Institute of Nuclear Physics of the Polish Academy of Sciences in Cracow. According to the researchers, current
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What was once considered the “Achilles heel” of lung cancer tumors, as Amgen puts it, now has an FDA-approved treatment in the company’s KRAS inhibitor, Lumakras.  The agency approved Lumakras on Friday, three months ahead of schedule, as the first treatment for non-small cell lung cancer (NSCLC) with a particular genetic mutation called KRAS G12C. Once considered
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Identifying markers that indicate severe COVID-19 disease trajectories could lead to early medical interventions and help reduce morbidity and mortality. In a new study posted to the bioRxiv* preprint server, a prospective cohort of patients with COVID-19 exhibited distinct features of the IgG fragment antigen-binding (Fab) and fragment crystallizable (Fc) domains, predicting two distinct disease
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Features of large systems yielded from tiny simulations with super-resolution techniques Tokyo, Japan – Researchers from Tokyo Metropolitan University have enhanced “super-resolution” machine learning techniques to study phase transitions. They identified key features of how large arrays of interacting “particles” behave at different temperatures by simulating tiny arrays before using a convolutional neural network to
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MitoARCUS construct design Precision BioSciences used in silico predictions and directed evolution methods to re-engineer I-CreI, to recognize the m.5024C>T point mutation as described26,27. A peptide linker was used to fuse both homodimers into a monomeric structure26,27. The specificity of the mitoARCUS was initially confirmed in CHO cells using an engineered split-GFP assay as described
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The La Jolla Institute for Immunology (LJI) is partnering with Synbal, Inc., a preclinical biotechnology company based in San Diego, CA, to develop multi-gene, humanized mouse models for COVID-19 research. The research at LJI will be led by Professor Sujan Shresta, Ph.D., a member of the Institute’s Center for Infectious Disease and Vaccine Research. “With
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Novo Nordisk is back for round two with a new Ozempic dosing regimen. The diabetes specialist resubmitted to the FDA on Friday after a March snub, renewing its bid to compete with Eli Lilly’s already approved higher dose. Novo’s resubmission aims to nab an approval for a once-weekly, 2-mg dose for Ozempic, a GLP-1 drug already approved for weekly dosing at
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Screening of methods We tested several promising automated systems developed for yeast enumeration in clear media (Nexcelom Cellometer X2, ThermoFisher Countess II and Bio-Rad TC20), and found that their applicability was very limited for lignocellulose-based samples. Cellulose and lignin in the media absorbed dyes and disturbed cell identification. The wide variety of particle sizes and
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UNIVERSITY PARK, Pa. — Developing new ultrathin metal electrodes has allowed researchers to create semitransparent perovskite solar cells that are highly efficient and can be coupled with traditional silicon cells to greatly boost the performance of both devices, said an international team of scientists. The research represents a step toward developing completely transparent solar cells.
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