These Oncotarget findings suggest that PL reduces tumor growth and induces cell death by regulating the cell cycle Oncotarget published “Piperlongumine promotes death of retinoblastoma cancer cells” which reported that while retinoblastoma initiation is triggered by the inactivation of both alleles of the retinoblastoma tumor suppressor gene in the developing retina, tumor progression requires additional
Month: May 2021
Welcome to this week’s Chutes & Ladders, our roundup of hirings, firings and retirings throughout the industry. Please send the good word—or the bad—from your shop to Fraiser Kansteiner, and we will feature it here at the end of each week. Next-gen T-cell player Neogene bolsters U.S. team, adding Bristol Myers vet as COO Neogene
With a tumultuous year behind us, 2021 is set out to spell change for many startups in the European biotech ecosystem. Following the Covid-19 pandemic and Brexit, the European biotech startup landscape has seen some big changes over the course of the past year. Jason Mellad and Dan Rooke, CEO and COO of the Cambridge-based
Development of the mapping population The cross between TMS98/0505 and TMS98/0581 (Population B parental lines) gave good flowering to generate seeds. There was good genetic variation in plant formation at the nursery. While a high number of the seedlings showed good development, many of the genotypes had extremely stunted growth. Once a genotype could support
Malignant tumor cells undergo mechanical deformation more easily than normal cells, allowing them to migrate throughout the body. The mechanical properties of prostate cancer cells treated with the most commonly used anti-cancer drugs have been investigated at the Institute of Nuclear Physics of the Polish Academy of Sciences in Cracow. According to the researchers, current
What was once considered the “Achilles heel” of lung cancer tumors, as Amgen puts it, now has an FDA-approved treatment in the company’s KRAS inhibitor, Lumakras. The agency approved Lumakras on Friday, three months ahead of schedule, as the first treatment for non-small cell lung cancer (NSCLC) with a particular genetic mutation called KRAS G12C. Once considered
Clinical diagnostics company Novacyt has announced that it has taken legal advice regarding its ongoing dispute with the Department of Health and Social Care (DHSC). In April, Novacyt announced that it was in a dispute with the DHSC over its second supply contract for COVID-19 testing kits, adding that the issues may have a direct
Is collecting near real time data the key to unlocking improvements in patient experience and national benchmarking? Small things can go a long way in terms of improving patient experience, but healthcare facilities cannot fix what they don’t know is broken. In the first of our series of articles from the Patient Experience: Empathy and
Identifying markers that indicate severe COVID-19 disease trajectories could lead to early medical interventions and help reduce morbidity and mortality. In a new study posted to the bioRxiv* preprint server, a prospective cohort of patients with COVID-19 exhibited distinct features of the IgG fragment antigen-binding (Fab) and fragment crystallizable (Fc) domains, predicting two distinct disease
Features of large systems yielded from tiny simulations with super-resolution techniques Tokyo, Japan – Researchers from Tokyo Metropolitan University have enhanced “super-resolution” machine learning techniques to study phase transitions. They identified key features of how large arrays of interacting “particles” behave at different temperatures by simulating tiny arrays before using a convolutional neural network to
HCW Biologics has filed to raise up to $50 million in an IPO. The money will set HCW up to take two immunotherapy treatments into the clinic in solid tumors and an autoimmune disorder. Florida-based HCW licensed rights to use its most advanced candidate, HCW9201, to Wugen, which is using the molecule in the generation
Vienna has a booming life sciences sector that has rapidly grown over the last decade. Here are 15 biotech companies in the city you should know about. Vienna might not be the first place that springs to mind when thinking of biotech centers of excellence. But Austria has given its bigger neighbors a run for
MitoARCUS construct design Precision BioSciences used in silico predictions and directed evolution methods to re-engineer I-CreI, to recognize the m.5024C>T point mutation as described26,27. A peptide linker was used to fuse both homodimers into a monomeric structure26,27. The specificity of the mitoARCUS was initially confirmed in CHO cells using an engineered split-GFP assay as described
The La Jolla Institute for Immunology (LJI) is partnering with Synbal, Inc., a preclinical biotechnology company based in San Diego, CA, to develop multi-gene, humanized mouse models for COVID-19 research. The research at LJI will be led by Professor Sujan Shresta, Ph.D., a member of the Institute’s Center for Infectious Disease and Vaccine Research. “With
Novo Nordisk is back for round two with a new Ozempic dosing regimen. The diabetes specialist resubmitted to the FDA on Friday after a March snub, renewing its bid to compete with Eli Lilly’s already approved higher dose. Novo’s resubmission aims to nab an approval for a once-weekly, 2-mg dose for Ozempic, a GLP-1 drug already approved for weekly dosing at
Janssen’s IL-23 inhibitor Tremfya has been accepted for NHS use by the UK’s National Institute for Health and Care Excellence (NICE) for the treatment of active psoriatic arthritis (PsA). Tremfya (guselkumab) is a fully human monoclonal antibody (mAb) designed to selectively bind to and inhibit the IL-23 receptor – an key driver of progression in
In this latest podcast, pharmaphorum spoke to Andrew Meade, life sciences lead UK and Ireland at Accenture, about the trends that emerged in this year’s Q1 results season. Meade talked about the prospects for the industry as the UK and other economies beginning to recover from the devastating pandemic. He discussed how COVID vaccines have
To mark World Vape Day, BAT has today published a comprehensive review of the scientific evidence for vaping products (e-cigarettes), their potential health effects and their role in Tobacco Harm Reduction. This review shows that, over the past decade, the number of people who incorrectly believe vaping is as harmful or more harmful than smoking
Screening of methods We tested several promising automated systems developed for yeast enumeration in clear media (Nexcelom Cellometer X2, ThermoFisher Countess II and Bio-Rad TC20), and found that their applicability was very limited for lignocellulose-based samples. Cellulose and lignin in the media absorbed dyes and disturbed cell identification. The wide variety of particle sizes and
UNIVERSITY PARK, Pa. — Developing new ultrathin metal electrodes has allowed researchers to create semitransparent perovskite solar cells that are highly efficient and can be coupled with traditional silicon cells to greatly boost the performance of both devices, said an international team of scientists. The research represents a step toward developing completely transparent solar cells.
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