A new method for identifying quantum orbits enables photoelectron spectroscopy via tunneling ionization to provide attosecond temporal and subangstrom spatial resolution measurement of electron dynamics Credit: Y. Zhang Electron motion in atoms and molecules is of fundamental importance to many physical, biological, and chemical processes. Exploring electron dynamics within atoms and molecules is essential for
Month: June 2021
ArriVent Biopharma has raised up to $150 million to in-license assets from China and other emerging biotech hubs and develop them for use in other markets. The biotech has already picked up ex-China rights to an EGFR TKI that it plans to study in non-small cell lung cancer (NSCLC) patients in the U.S. Traditionally, biopharma
Analysts are abuzz over GSK’s co-development deal with immuno-oncology specialist iTeos Therapeutics earlier this month, wondering if it overpaid for the Belgian company’s next-generation checkpoint inhibitor. GSK’s oncology deal with iTeos earlier this month centered on an antibody drug that blocks an immune checkpoint called TIGIT. The candidate is currently in phase I testing for
Nanomaterial synthesis All chemicals used for synthesis and modification were purchased from Sigma-Aldrich and used directly, unless otherwise stated. Nanoparticles of diverse size, shape, and material composition were synthesized according to the following methods. Gold nanosphere (Au NS) was synthesized by rapidly injecting gold precursors into a pre-heated surfactant solution47. Briefly, oleylamine (5 ml) was refluxed
A new corona test developed at the University Hospital Bonn can analyze a large number of swabs simultaneously using sequencing technology and has a similarly high sensitivity as the common qPCR test. The innovative method offers great potential, especially for systematic testing in daycare centers, schools or companies. Today, the results of the study on
Even though Biogen’s Alzheimer’s drug Aduhelm scored a hotly debated, wide-labeled FDA nod earlier this month, the treatment still isn’t worth more than a mere 15% of the annual $56,000 list price the company is charging, a prominent U.S. drug cost watchdog argues. The Institute for Clinical and Economic Review (ICER) said in a revised
BioMarin has resubmitted a marketing authorisation application (MAA) for its haemophilia A gene therapy valoctocogene roxaparvovec to the European Medicines Agency (EMA), the company announced yesterday. BioMarin initially withdrew the EU marketing application for the gene therapy – also known as Roctavian – last year, after stating that it was unable to provide the data
A study analyzing the association between a wide variety of prenatal and childhood exposures and neuropsychological development in school-age children has found that organic food intake is associated with better scores on tests of fluid intelligence (ability to solve novel reasoning problems) and working memory (ability of the brain to retain new information while it
Patient recruitment has begun in a National Institutes of Health (NIH) trial of two digital therapeutics (DTx) for people with opioid use disorder (OUD), developed by Pear Therapeutics and Chess Health. The CTN-0100 study is test strategies to help keep people with OUD on drug treatment, improve the chances that those stabilised with drug treatments
Research should improve long-term cold storage of everything from foods to medicines Credit: Photo by V. Dia, courtesy UTIA. Have you ever wondered why ice grows ‘out of nowhere’ on that pizza or ice cream you forgot about in the back of your freezer? The phenomenon is called ice recrystallization, and it’s a problem that
Orphazyme is taking the ax to most of its workforce after its beleaguered single asset has been hit by rejections and serial flops in the clinic. The history of the drug has been a horror show: Back in March, the Copenhagen-based biotech’s experimental drug, known as arimoclomol, was being tested in 150 patients against placebo
Mitotic cell collection Chinese Hamster Ovary (CHO) cells were procured from National Centre for Cell Science, India. Cells were cultured in DMEM supplemented with 10% FBS. For mitotic cell collection, cells were harvested from a nearly confluent culture, seeded in optimum density of ~ 5 million/175 cm2 flask. The cells were allowed to attach and grow for ~ 16 h
A collaborative effort between the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Massachusetts Institute of Technology (MIT) recently published their findings on how novel technology can be incorporated into standard face masks to detect the presence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Face Mask that can detect SARS-CoV-2.
AbbVie has pegged much of its post-Humira hopes on its next-gen immunology med Rinvoq, which now appears one step closer toward what could be a $2 billion indication in ulcerative colitis. The Chicago-based pharma said on Tuesday that its rheumatoid arthritis drug “significantly” topped placebo at helping moderate to severe ulcerative colitis patients reach clinical remission after a
French pharma company Sanofi has announced that it will invest €400m into a new facility focused on solely on the development and delivery of next-generation mRNA-based vaccines. The mRNA ‘centre of excellence’ will employee approximately 400 staff in a bid to integrate end-to-end mRNA vaccine capabilities. This will include bringing together dedicated research & development,
Eight volunteers who received a complete dose or a single dose of an mRNA vaccine or the ChAdOx1 vaccine after a dose of a trial gorilla adenovirus vaccine showed a significantly high level of antibodies and T cell response against SARS-CoV-2. Although several vaccines have now been approved to combat the coronavirus disease (COVID-19) pandemic,
Exelixis has suffered a blow to its efforts to expand the use of Cabometyx into additional indications after reporting mixed results in a phase 3 trial in liver cancer. The COSMIC-312 study is comparing Cabometyx (cabozantinib) given alongside Roche’s cancer immunotherapy Tecentriq (atezolizumab) to Bayer’s Nexavar (sorafenib) as a first-line treatment for hepatocellular carcinoma (HCC),
In first-of-its kind research led by a University of Massachusetts Amherst psychotherapy researcher, mental health care patients matched with therapists who had a strong track record of treating the patients’ primary concerns had better results than patients who were not so matched. In addition, this “match effect” was even more beneficial and pronounced for patients
AstraZeneca has appointed Susan Galbraith, Ph.D., as the successor to the late José Baselga. Galbraith is taking up the post of executive vice president, oncology research and development after spending 11 years working on cancer therapies at AstraZeneca. The passing of Baselga in March forced AstraZeneca to search for a new person to head up
Food waste is one of the many environmental problems caused by modern agriculture. Biotechnology innovations may help us tackle it by turning waste into energy. For decades now, bioenergy has been posited as a renewable and clean source of energy. Biomass, particularly from forestry, is the largest source of renewable energy in the UK. However,
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