Month: June 2021

A new method for identifying quantum orbits enables photoelectron spectroscopy via tunneling ionization to provide attosecond temporal and subangstrom spatial resolution measurement of electron dynamics Credit: Y. Zhang Electron motion in atoms and molecules is of fundamental importance to many physical, biological, and chemical processes. Exploring electron dynamics within atoms and molecules is essential for
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Analysts are abuzz over GSK’s co-development deal with immuno-oncology specialist iTeos Therapeutics earlier this month, wondering if it overpaid for the Belgian company’s next-generation checkpoint inhibitor.  GSK’s oncology deal with iTeos earlier this month centered on an antibody drug that blocks an immune checkpoint called TIGIT. The candidate is currently in phase I testing for
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Nanomaterial synthesis All chemicals used for synthesis and modification were purchased from Sigma-Aldrich and used directly, unless otherwise stated. Nanoparticles of diverse size, shape, and material composition were synthesized according to the following methods. Gold nanosphere (Au NS) was synthesized by rapidly injecting gold precursors into a pre-heated surfactant solution47. Briefly, oleylamine (5 ml) was refluxed
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Even though Biogen’s Alzheimer’s drug Aduhelm scored a hotly debated, wide-labeled FDA nod earlier this month, the treatment still isn’t worth more than a mere 15% of the annual $56,000 list price the company is charging, a prominent U.S. drug cost watchdog argues.   The Institute for Clinical and Economic Review (ICER) said in a revised
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BioMarin has resubmitted a marketing authorisation application (MAA) for its haemophilia A gene therapy valoctocogene roxaparvovec to the European Medicines Agency (EMA), the company announced yesterday. BioMarin initially withdrew the EU marketing application for the gene therapy – also known as Roctavian – last year, after stating that it was unable to provide the data
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A study analyzing the association between a wide variety of prenatal and childhood exposures and neuropsychological development in school-age children has found that organic food intake is associated with better scores on tests of fluid intelligence (ability to solve novel reasoning problems) and working memory (ability of the brain to retain new information while it
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Mitotic cell collection Chinese Hamster Ovary (CHO) cells were procured from National Centre for Cell Science, India. Cells were cultured in DMEM supplemented with 10% FBS. For mitotic cell collection, cells were harvested from a nearly confluent culture, seeded in optimum density of ~ 5 million/175 cm2 flask. The cells were allowed to attach and grow for ~ 16 h
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A collaborative effort between the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Massachusetts Institute of Technology (MIT) recently published their findings on how novel technology can be incorporated into standard face masks to detect the presence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Face Mask that can detect SARS-CoV-2.
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AbbVie has pegged much of its post-Humira hopes on its next-gen immunology med Rinvoq, which now appears one step closer toward what could be a $2 billion indication in ulcerative colitis.  The Chicago-based pharma said on Tuesday that its rheumatoid arthritis drug “significantly” topped placebo at helping moderate to severe ulcerative colitis patients reach clinical remission after a
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French pharma company Sanofi has announced that it will invest €400m into a new facility focused on solely on the development and delivery of next-generation mRNA-based vaccines. The mRNA ‘centre of excellence’ will employee approximately 400 staff in a bid to integrate end-to-end mRNA vaccine capabilities. This will include bringing together dedicated research & development,
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Eight volunteers who received a complete dose or a single dose of an mRNA vaccine or the ChAdOx1 vaccine after a dose of a trial gorilla adenovirus vaccine showed a significantly high level of antibodies and T cell response against SARS-CoV-2. Although several vaccines have now been approved to combat the coronavirus disease (COVID-19) pandemic,
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Exelixis has suffered a blow to its efforts to expand the use of Cabometyx into additional indications after reporting mixed results in a phase 3 trial in liver cancer. The COSMIC-312 study is comparing Cabometyx (cabozantinib) given alongside Roche’s cancer immunotherapy Tecentriq (atezolizumab) to Bayer’s Nexavar (sorafenib) as a first-line treatment for hepatocellular carcinoma (HCC),
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In first-of-its kind research led by a University of Massachusetts Amherst psychotherapy researcher, mental health care patients matched with therapists who had a strong track record of treating the patients’ primary concerns had better results than patients who were not so matched. In addition, this “match effect” was even more beneficial and pronounced for patients
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Food waste is one of the many environmental problems caused by modern agriculture. Biotechnology innovations may help us tackle it by turning waste into energy. For decades now, bioenergy has been posited as a renewable and clean source of energy. Biomass, particularly from forestry, is the largest source of renewable energy in the UK. However,
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