Month: July 2021

Bristol-Myers Squibb is in a battle with Merck & Co for position in the upper gastrointestinal cancer immunotherapy market, and has just reinforced its position with an EU approval in the post-surgery (adjuvant) setting. The European Commission has approved Opdivo (nivolumab) as the first-ever adjuvant immunotherapy for patients with oesophageal or gastroesophageal junction (GEJ) cancer,
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This Oncotarget study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas Oncotarget published “TERT and its binding protein: overexpression of GABPA/B in high grade gliomas” which reported that all GA-binding proteins progress through the glioma grades and have the highest expression levels in secondary
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In the following, detailed information is presented on: (1) the analytical mathematical framework of the two nested shear lag models including the connection to a single elasto-plastic rheological element (“Two nested shear lag models for a mineralised collagen fibre” section); (2) the analytical mathematical framework of a single rheological unit for the fibre composite with
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The Medicines Patent Pool (MPP) and the World Health Organization (WHO), Afrigen Biologics (PTY) Limited, the Biologicals and Vaccines Institute of Southern Africa (Biovac), the South African Medical Research Council (SAMRC) and Africa Centres for Disease Control and Prevention (Africa CDC) have signed a letter of intent to address the global imbalance of manufacturing capacity
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The UK’s National Institute for Health and Care Excellence (NICE) has published a new guideline of the rare syndrome vaccine-induced immune thrombocytopenia and thrombosis (VITT) associated with COVID-19 vaccination. The new guideline outlines how to diagnose people with suspected VITT and what tests should be conducted to confirm they have this conditions. Thrombocytopenia is characterised
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A rise in cases of short-sightedness (myopia) among children in Hong Kong may be linked to a significant decrease in the time they have been able to spend outdoors and a sharp rise in screen time during the coronavirus pandemic, suggests research published online in the British Journal of Ophthalmology. By September 2020, more than
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Citrus fruits from the mandarin family have important commercial value but how their diversity arose has been something of a mystery Researchers analyzed the genomes of the East Asian varieties and found a second center of diversity in the Ryukyu Islands along with the previously known center in the mountains of southern China They discovered
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Researchers have been using DNA testing technology to detect traces of the SARS-CoV-2 virus behind Covid-19 in wastewater streams in order to predict and prevent outbreaks locally.  Wastewater testing can be a useful method to study the behavior of people living in a specific region. For example, a European study conducted back in 2014 looked
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Nature-inspired processes Nature-inspired processes are artificial processes which enable the emulation of a certain natural process such as photosynthesis. An artificial photosynthesis process can therefore be used to harvest solar energy or for solar-to-fuel conversion. A nature-inspired process in this case is triggered by the observation of photosynthesis of plant/tree leaves (storing energy in the
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The development and distribution of effective vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus responsible for the coronavirus disease 2019 (COVID-19), is estimated to have already saved the lives of hundreds of thousands of people in the United States alone. In addition to the vaccines that have already been
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GlaxoSmithKline’s antibody drug Nucala may not have been the first biologic approved in nasal polyps—that distinction goes to Sanofi and Regeneron’s Dupixent. But on Thursday, it did become the first IL-5 inhibitor to break into the indication, notching a win over AstraZeneca’s would-be rival Fasenra. The FDA gave Nucala the green light to treat chronic rhinosinusitis
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French pharma company Ipsen has entered into a new collaboration agreement with BAKX Therapeutics focused on an oral small-molecule activator of BAX for the potential treatment of leukaemia, lymphoma and solid tumours. Under the terms of the deal, Ipsen will collaborate with BAKX Therapeutics to research, develop, manufacture and commercialise BKX-001 in these oncology indications.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV-1 gain entry to host cells by interacting with the ACE2 receptor, while the closely related MERS-CoV enters human cells by binding with dipeptidyl-peptidase. Besides these major receptors each virus also interacts with a number of additional surface proteins or glycans that aid in initial
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Collaboration signifies strong commitment by all stakeholders to maintain the journal’s high standards and expand its global prominence New York, July 26, 2021 – The American College of Medical Genetics and Genomics (ACMG), the only nationally recognized US medical professional organization solely dedicated to improving health through the practice of medical genetics and genomics, and
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