Month: November 2021

Challenging targets, such as membrane proteins or protein-protein interactions were considered undruggable in the past. However, today a variety of screening methods can be used to help develop drugs against these formerly undruggable targets. Discover more in this infographic! There are thousands of challenging targets against which it is incredibly difficult to develop a drug.
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Extract preparation with the basic protocol In this work, ASE was chosen for the extraction of potentially bioactive substances from microalgal biomass under defined conditions. Due to reports classifying EtOH as a safe and environmentally friendly solvent suitable for the extraction of natural value products from microalgae36,45, 95% EtOH was chosen. Considering a possible thermolability
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The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has taken over 5.21 million lives so far, over less than two years. At present, the emergence of new variants with higher transmissibility and the ability to evade host immune defenses threatens the world with further, possibly more destructive,
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Despite Biogen’s best efforts, Tecfidera generics are here to stay, it seems.  A U.S. appeals court has declined to resurrect a key patent on Biogen’s once-stalwart multiple sclerosis med Tecfidera, according to court documents filed (PDF) Tuesday. It’s the latest spot of trouble for the struggling blockbuster, which succumbed to its first generic competitor in
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The currently available tests for detecting antigen load in patients suspected of being infected with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) include the rapid antigen and reverse-transcriptase polymerase chain reaction (RT-PCR) tests. Several studies have compared the clinical sensitivity of molecular assays and rapid antigen tests on nasopharyngeal or nasal swab samples to detect
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CORVALLIS, Ore. – New Oregon State University research shows that warm-water habitats can be critically important for the survival of cold-water fish such as trout and salmon. CORVALLIS, Ore. – New Oregon State University research shows that warm-water habitats can be critically important for the survival of cold-water fish such as trout and salmon. In
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Photocrosslinked gelatin hydrogel preparation Gelatin (beMatrix, Nitta Gelatin, Inc., Japan) was dissolved in Milli-Q ultrapure water at 10 or 5 wt% at 37 °C. The visible light photoinitiator, pentamethylcyclopentadienyl triphenylphosphine ruthenium chloride, and sodium persulfate (10 mM; Advanced BioMatrix, Inc., CA) were gently mixed with gelatin solution immediately before use. LED (Thorlab, Inc., wavelength: 455 nm) was used for
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Companies are testing their COVID-19 vaccines against the new variant, omicron. An FDA advisory committee will meet tomorrow to discuss its recommendation for Merck’s COVID-19 antiviral. The worldwide case count stood at more than 261.98 million Monday afternoon, with more than 5.2 million reported deaths, according to Johns Hopkins University’s COVID-19 dashboard. Please read below for
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Scott Lippman, MD, will launch and lead the PreCancer Genome Atlas, a National Cancer Institute (NCI)-sponsored effort to map in time and space all of the molecular, cellular and structural characteristics of premalignant lesions and how they evolve into invasive cancers. He will retain his appointment as associate vice chancellor for cancer research and care
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At first glance, Antarctica seems inhospitable. Known for howling gales and extremely cold temperatures, the continent is blanketed with a mile-thick ice shelf. Occasional elephant seals and seabirds fleck the glacial shorelines. At first glance, Antarctica seems inhospitable. Known for howling gales and extremely cold temperatures, the continent is blanketed with a mile-thick ice shelf.
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Plant materials and growth conditions Tomato (Solanum lycopersicum cv MicroTom) and other commercial accessions were grown in culture chambers (14 h day/10 h night cycle, 25/20 °C day/night temperature, 80% relative humidity). After 5% sodium hypochlorite sterilization, tomato seeds were sown on 0,5x Murashige and Skoog medium pH 5.9 with 0.8% (w/v) agar and transferred to the soil
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