Month: May 2022

Innovations in cancer immunotherapy have achieved clinical success by considerably increasing the survival rate of patients undergoing cancer treatment. However, there still exists an unmet medical need due to the low response rate to checkpoint inhibitors caused by the low immune reactivity of cancer cells in “cold” tumors. In their efforts to turn “cold” tumors
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Preparation and FACS of hPBMCs Leukocytes were isolated from whole blood by density gradient centrifugation using Ficoll-Paque (Sigma-Aldrich). If not used immediately, cells were cryopreserved in fetal bovine serum (FBS) + 10% DMSO (Sigma-Aldrich). Prior to fluorescence-activated cell sorting (FACS), cells were thawed, resuspended in 1x PBS + 2% FBS and stained with an fluorescein isothiocyanate-conjugated mouse anti-human CD45
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Built on the emerging ecosystems of Web3 and blockchain, decentralized autonomous organizations (DAOs) allow communities to collectively fund and advance biotech research. The majority of biotech companies are highly centralized with much of the data siloed away in their proprietary databases. Companies have no incentives to openly share this data, which slows down progress in
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A major study has revealed the “global collateral damage” caused by the disruption to cardiac services from the COVID-19 pandemic. The researchers warn that problems with heart health will “…continue to accrue unless mitigation strategies are speedily implemented”. In the two years from December 2019, when health systems around the world were under extreme pressure
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For decades, RAS has existed as an elusive therapeutic target, and drugging this high-value oncogene was deemed impossible. Despite this, the first-ever FDA-approved KRAS G12C inhibitor has demonstrated that RAS is in fact druggable and that drugging this protein unlocks a world of successful therapeutic interventions. Now, the future looks bright for treating patients with cancers harboring
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Ethial statement All experiments were approved by the Ethics Committee in Animal Experimentation of Val de Loire (CEEA Vdl) (certificate of authorisation to experiment on living animals APAFIS number 10237-201706151202940v3). The CEEA vdl is registered by the National Committee ‘Comité National de Réflexion Ethique sur l’Expérimentation Animale’ under the number 19. All experiments were performed
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Approval provides another step forward in transforming multiple myeloma outcomes and eliminating the disease The European Commission (EC) has approved Janssen’s CAR-T therapy, Carvykti, for adults with heavily pre-treated, relapsed and refractory multiple myeloma, marking the treatment’s first approval outside of the US. Carvykti – also known as ciltacabtagene autoleucel or cilta-cel – has been
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A hospital is made up of various units that work together to provide exemplary patient care. Some of the units involved include surgical suits, emergency areas, diagnostic imaging departments, critical care units, newborn intensive care areas, and laboratories. The design of a health facility is guided by its primary functions, which include research, inpatient and
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U.S. biotech company HotSpot Therapeutics, Inc. is looking to increase its drug development and discovery efforts by partnering with Indian data and digital insights company Excelra. HotSpot discovers and develops small molecule allosteric therapies for the treatment of cancer and autoimmune diseases.  What are allosteric therapies? In the journal ACS Medicinal Chemistry Letters, Ahmed F.
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Accelerating the Discovery, Translation & Large-Scale Manufacturing of Exosomes & EVs With 3 days of unrivaled content and two dedicated tracks, this year’s summit will be putting the spotlight on cutting-edge strategies from discovery, translation, and clinical development of modified and unmodified exosomes and EVs, to accelerate this emerging field forward. Built with biopharmaceutical industry insights, this in-person conference will delve
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Tokyo, Japan – Researchers from Tokyo Metropolitan University have developed a new carbon capture system which removes carbon dioxide directly from the atmosphere with unprecedented performance. Isophorone diamine (IPDA) in a “liquid-solid phase separation” system was found to remove carbon dioxide at the low concentrations contained in the atmosphere with 99% efficiency. The compound is
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